Joan Rivers has died at the age of 81. The legendary comedian and TV host was taken off of life support at Mount Sinai Hospital in New York City on Thursday.

An investigation is now underway which will look into the clinic where Rivers first went into cardiac and respiratory arrest on Aug. 28.

"My mother's greatest joy in life was to make people laugh," Melissa Rivers said in a statement, according to NBC News. "Although that is difficult to do right now, I know her final wish would be that we return to laughing soon."

Melissa and her 13-year-old son grandson Cooper rushed from their Malibu home to New York upon hearing news of Rivers' hospitalization.

Eight days before she died, the comedian had been undergoing throat surgery on her vocal cords at a New York clinic when she reportedly stopped breathing and went into cardiac arrest. An emergency call was made from the clinic and Rivers' was quickly moved to Mount Sinai Hospital.

It has been a tumultuous few days for the fashion critic and her family. After Rivers condition upgraded from critical to stable, she was put into a medically induced coma and moved to the ICU. However, when taken out of the coma, Rivers was transferred from the ICU and placed in a private room.

The Daily News reported that Rivers' hospital room was filled with flowers and her daughter Melissa continued to do her make-up each day while the family considered what would be best for the comedian as she relied on life support.

According to the publication, an emergency medicine doctor at a "prominent New York hospital" explained that the family's decision to move Rivers to a private room could signal the star's impending passing.

"If she is off all life support and in a private room, and resting comfortably, it's possible the family is waiting for nature to take its course," said the medical professional.

The renowned comedian made headlines for her brash, often politically incorrect take on red carpet fashion, which always seemed to bring a hilarious, lively air to large Hollywood events. She spoke to several generations of fans on her E! Network show "Fashion Police," which she hosted beginning in 2010 alongside Giuliana Rancic, Kelly Osbourne, and George Kotsiopoulous.

Production of the show is currently on hiatus due to Rivers' health crisis and consequential passing.

Yorkville Endoscopy, the Manhattan surgical center where Rivers stopped breathing last Thursday, is currently under scrutiny by the State Health Department, which is "investigating the matter," according to agency's spokesman James O'Hare, who spoke to the Daily News.

"The center was carefully designed in order to maximize patient privacy and comfort throughout every phase of their visit," said Dr. Lawrence B. Cohen, medical director and board member of Yorkville. "We believe that this will help to reduce the barriers that sometimes prevent patients from receiving needed endoscopic care."

According to the Daily News, a 93-year-old man who underwent the same medical procedure as Rivers, sued the clinic in 2004 for complications during the surgery that led to him contracting pneumonia. He lost the case.